+90 5331418641
Schedule an Appointment
Categories Scientific article

Michal Novoselsky Persky 1, Anat Hershko-Klement 1, Amy Solnica 1 2, Yuval Bdolah 3, Arye Hurwitz 3, Mali Ketzin El Gilad 1, Iris Nefesh 1, Efrat Esh-Broder 1

Affiliations Expand

Free article

Abstract

Background: Physiological selection of spermatozoa for ICSI (PICSI) is a sperm selection method based on sperm binding to hyaluronic acid. Previous studies on the effect of hyaluronic acid binding assays on fertilization and embryo quality have shown inconsistent results. Previous sibling oocyte studies have not found a significant improvement in fertilization or embryo development with hyaluronic acid binding assays.

Objective: To compare fertilization and embryo development between standard intracytoplasmic sperm injection (ICSI) and PICSI in sibling oocytes.

Materials and methods: This is a retrospective analysis of all in vitro fertilization (IVF) cycles between January 2017 and April 2020 in which sibling oocytes were randomly fertilized by both ICSI and PICSI. Fertilization rate and the rate of embryos eligible for transfer were compared.

Results: Forty-five IVF cycles, in which 257 oocytes were fertilized with PICSI and 294 with standard ICSI, were compared. Most of the patients included in the study had previous failures of fertilization, poor embryonic development, implantation failure, or miscarriage. All but two of the patients had at least one previous unsuccessful IVF cycle. Both fertilization rates (71% vs. 83%) and transfer eligible embryo rates (38% vs. 51%) were significantly higher in PICSI fertilized oocytes (p = 0.008 and p = 0.01 respectively).

Discussion: Our study is the largest sibling oocyte study comparing ICSI and PICSI, and the first to find a significant improvement in fertilization and embryo quality with PICSI using sibling oocytes. The fact our cohort included almost exclusively couples with previous unsuccessful IVF cycles might suggest that PICSI should be used in selected cases.

Conclusion: PICSI improves fertilization rates and transfer eligible embryo rates in sibling oocytes in a selected study group.

Keywords: PICSI; hyaluronic acid ICSI; sibling oocytes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all “Cited by” articles

References

REFERENCES

    1. Rubino P, Vigano P, Luddi A, Piomboni P. The ICSI procedure from past to future: a systematic review of the more controversial aspects. Human Reprod. 2016;22(2):194-227.
    1. Jeyendran RS, Caroppo E, Rouen A, Anderson A, Puscheck E. Selecting the most competent sperm for assisted reproductive technologies. Fertil Steril. 2019;111(5):851-863.
    1. Worrilow KC, Eid S, Woodhouse D, et al. Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes-multicenter, double-blinded and randomized controlled trial. Human Reproduction (Oxford, England). 2013;28(2):306-314.
    1. Erberelli RF, Salgado RM, Pereira DH, Wolff P. Hyaluronan-binding system for sperm selection enhances pregnancy rates in ICSI cycles associated with male factor infertility. JBRA Assisted Reprod. 2017;21(1):2-6.
    1. Mokánszki A, Tóthné EV, Bodnár B, et al. Is sperm hyaluronic acid binding ability predictive for clinical success of intracytoplasmic sperm injection: PICSI vs. ICSI? Systems Biol Reprod Med. 2014;60(6):348-354.

Show all 14 references

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Female
  • Humans
  • Hyaluronic Acid*
  • Male
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Sperm Injections, Intracytoplasmic / methods*
  • Spermatozoa

Substances

  • Hyaluronic Acid

Related information

LinkOut – more resources

Previous
Next
Copyright © 2021 GYNISTIVF Clinic Turkey. All rights reserved.