Sravya Gudapati 1, Kamlesh Chaudhari 1, Deepti Shrivastava 1, Seema Yelne 2
Affiliations Expand
- PMID: 38694414
- PMCID: PMC11061269
- DOI: 10.7759/cureus.57357
Abstract
Preimplantation genetic testing (PGT) has become an integral component of assisted reproductive technology (ART), offering couples the opportunity to screen embryos for genetic abnormalities before implantation during in vitro fertilization (IVF). This comprehensive review explores the advancements and applications of PGT in IVF, covering its various types, technological developments, clinical applications, efficacy, challenges, regulatory aspects, and future directions. The evolution of PGT techniques, including next-generation sequencing (NGS) and comparative genomic hybridization (CGH), has significantly enhanced the accuracy and reliability of genetic testing in embryos. PGT holds profound implications for the future of ART by improving IVF success rates, reducing the incidence of genetic disorders, and mitigating the emotional and financial burdens associated with failed pregnancies and genetic diseases. Recommendations for clinicians, researchers, and policymakers include staying updated on the latest PGT techniques and guidelines, exploring innovative technologies, establishing clear regulatory frameworks, and fostering collaboration to maximize the potential benefits of PGT in assisted reproduction. Overall, this review provides valuable insights into the current state of PGT and its implications for the field of reproductive medicine.
Keywords: assisted reproductive technology (art); comparative genomic hybridization (cgh); genetic screening; in vitro fertilization (ivf); next-generation sequencing (ngs); preimplantation genetic testing (pgt).
Copyright © 2024, Gudapati et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
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