Many women are very curious about the answer to ‘why does IVF fail with good embryos?

In the IVF procedure, which had previously failed, couples are re-treated. The doctor makes a detailed examination, and it is investigated for what reasons there is no pregnancy. There isn’t much concern for partners who haven’t conceived once with the IVF procedure. However, if two or more IVF procedures have given good embryos, but pregnancy isn’t achieved, the doctor will do many tests.

First of all, the doctor investigates the reasons for the woman. The doctor looks for abnormalities in women that can prevent the embryo from attaching, such as intrauterine adhesions, polyps, or fibroids in the uterus. For this purpose, the doctor checks whether the uterine cavity is normal by introducing fluid into the uterus under the guidance of ultrasonography. This procedure is very simple and painless for the patient.

Hysterosalpingography (HSG) is also a method used to see such disorders. However, the hysteroscopic examination is preferred today due to the extremely painful nature of the HSG procedure and the risks of infection. Hysteroscopy is an easy method that gives the chance to examine in detail with a small camera system placed inside the uterus. At the same time, this procedure offers the convenience of correcting problems inside the uterus. In cases where the IVF procedure is unsuccessful, the doctor very often uses the hysteroscopy procedure.

Another reason that prevents the embryos from adhering is the accumulation of fluid in the woman’s tubes due to obstruction. In this case, which can be detected by ultrasonography and called hydrosalpinx, the doctor takes a film of the uterus. Alternatively, the doctor may perform a laparoscopy. The fluid accumulated in the tubes flows into the uterus, preventing the embryos from adhering or leading to miscarriage when pregnancy occurs. In this case, the doctor removes the tubes by laparoscopy. This increases the chances of pregnancy. Fluid collection in the tubes is one of the most important and most common reasons that reduce the chance of IVF in women.

Also, hormonal disorders prevent the embryo’s development and attachment to the uterus to a great extent. In thyroid gland diseases, the increase in the milk hormone secreted from the pituitary in the brain is also very significant. The doctor can identify these disorders by looking at the hormone levels in the blood. Polycystic Ovary Syndrome (PCOS) and the increase in insulin hormone caused by this disease make it difficult to conceive. For this purpose, pregnancy can be increased by giving diabetes medications that reduce insulin resistance.

Actions To Be Taken After IVF Failure is Determined

For a failed IVF procedure, when all the above investigations are normal in partners, the doctor takes a tissue sample from the uterus and culture and propagates this sample in a laboratory environment, and develops the embryos in this culture medium. With the endometrial co-culture technique, a small tissue sample from the uterus on the 21st day of the menstrual period is produced in a laboratory environment. An artificial intrauterine tissue is created. The embryos are grown in this tissue. Intrauterine tissue culture, rich in growth factors, nutrients, and proteins necessary for embryo development, thus supports embryo development. In addition, the antioxidants formed in the environment remove residues that may be harmful to the embryo. This technique is used as an alternative to artificial culture media in previously unsuccessful IVF cases.

If you have been unsuccessful in IVF treatment and want to have a baby, you can contact us immediately.